Arsenal have been drawn against Wigan Athletic in the FA Cup fourth round, while Chelsea will travel to Hull City in one of the standout ties.
The Gunners, who cruised past Portsmouth 4-1 in the third round, will host Wigan at the Emirates Stadium.
The tie revives memories of the 2014 FA Cup final, when Arsenal beat the Latics to end a long wait for silverware.
Chelsea, meanwhile, head to the MKM Stadium to face Hull in a fixture that carries added intrigue for new head coach Liam Rosenior, who previously played for and managed the Championship side.
Macclesfield FC’s reward for dumping out holders Crystal Palace is another home clash, this time against in-form Premier League side Brentford.
Keith Andrews’ team will be keen to avoid becoming the latest victims of a cup upset.
Liverpool host Barnsley on Monday evening and, if they progress, will meet Brighton in round four after the Seagulls’ shock victory over Manchester United at Old Trafford.
Manchester City will have to wait to learn their opponents, with the Salford City vs Swindon Town tie rearranged for January 20 following a frozen pitch postponement.
The pick of the round sees Aston Villa welcome fellow Premier League side Newcastle United to Villa Park.
FA Cup fourth round draw:
Liverpool or Barnsley vs Brighton
Stoke vs Fulham
Oxford United vs Sunderland
Southampton vs Leicester City
Wrexham vs Ipswich Town
Arsenal vs Wigan Athletic
Hull City vs Chelsea
Burton Albion vs West Ham United
Burnley vs Mansfield Town
Norwich City vs West Bromwich Albion
Port Vale vs Bristol City
Grimsby Town vs Wolves
Aston Villa vs Newcastle United
Manchester City vs Salford City or Swindon Town
Macclesfield FC vs Brentford
Birmingham City vs Leeds United
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